YIM Session 1: Pathogenesis of CLL

Co-Chair(s)

• 

  Elisa ten Hacken, PhD

  Assistant Professor
  Weill Cornell Medicine
  New York City, NY, United States
• 

  Basile Stamatopoulos, PhD

  Professor
  Jules Bordet Institute - Laboratory of Clinical Cell Therapy
  Brussels, Brussels Hoofdstedelijk Gewest, Belgium

Presentations:

• 8:10 AM – 8:20 AM EDT

  LYN kinase and its regulator CSK as key players in CLL-supporting macrophages
  

  Primary Author; Presenting Author: Viktoria Kohlhas, MSc – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Maximilian Koch, PhD – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Julia Saggau – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Hendrik Jestrabek – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Luca Schreurs – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Rebekka Zölzer – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Rocio Rebollido-Rios, PhD – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Alexander F. vom Stein – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: Daniel Bachurski – Department I for Internal Medicine, University Hospital Cologne

  Co-Author: France Rose, PhD – Center for Molecular Medicine Cologne CMMC, University of Cologne

  Co-Author: Katarzyna Bozek, PhD – Center for Molecular Medicine Cologne CMMC, University of Cologne

  Co-Author: Simon Tröder, PhD – CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne

  Co-Author: Branko Zevnik, PhD – CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne

  Co-Author: Björn Häupl, PhD – Department of Medicine II, Hematology/Oncology, Goethe University Frankfurt

  Co-Author: Thomas Oellerich, MD – Department of Medicine II, Hematology/Oncology, Goethe University Frankfurt

  Co-Author: Michael Hallek, MD – Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne

  Co-Author: Phuong-Hien Nguyen, PhD – Department I for Internal Medicine; Center for Molecular Medicine Cologne CMMC, University of Cologne
• 8:20 AM – 8:30 AM EDT

  PI3K inhibitor-resistant B-cell lymphomas show distinct functional phenotypes characterized by sensitivity to Bcl-2- or proteasome-inhibition
  

  Primary Author; Presenting Author: Johanne Uthus Hermansen, MSc – Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital

  Co-Author: Paschalis Athanasiadis, MSc – Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital

  Co-Author: Yanping Yin, PhD – Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital

  Co-Author: Alberto J. Arribas, PhD – Institute of Oncology Research, Faculty of Biomedical Sciences, USI

  Co-Author: Lene Skou Nilsen, MD – University Hospital of North Norway

  Co-Author: Anthony R. Mato, MD – Memorial Sloan Kettering Cancer Center

  Co-Author: Fransesco Bertoni, MS, PhD – Institute of Oncology Research, Faculty of Biomedical Sciences, USI

  Co-Author: Geir E. Tjønnfjord, MD, PhD – Department of Haematology, Oslo University Hospital

  Co-Author: Tero Aittokallio, PhD – Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital

  Co-Author: Sigrid S. Skånland, PhD – Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital
• 8:30 AM – 8:40 AM EDT

  The RNA-binding protein Musashi2 is regulated by NOTCH1/KLF4 pathway and support tumor survival keeping CLL cells in proliferative niches during disease progression
  

  Primary Author; Presenting Author: Juliana Querol Rivas, Biotechnol. Eng. – Institut Pasteur de Montevideo

  Co-Author: Magalí Torres, Biochem.

  Co-Author: Gabriel Fernandez, BSc

  Co-Author: Eugenia Payque, Biotechnol. Eng. – Institut Pasteur de Montevideo

  Co-Author: Rita Uría, MD – Institut Pasteur de Montevideo

  Co-Author: Maria Elena Marquez, PhD – Institut Pasteur de Montevideo

  Co-Author: Shih-Shih Chen, PhD – Feinstein Institute for Medical Research

  Co-Author: Ana Ines Landoni, MD – Hematology Service, Hospital Maciel, ASSE

  Co-Author: Cecilia Guillermo, MD – Hematology Department, Hospital de Clínicas

  Co-Author: Nicholas Chiorazzi, MD, PhD – The Feinstein Institutes for Medical Research, Northwell Health

  Co-Author: Pablo Oppezzo, PhD – Institut Pasteur de Montevideo

  Co-Author: Florencia L. Palacios, PhD – Institut Pasteur de Montevideo
• 8:40 AM – 8:50 AM EDT

  ZMYM3 Mutations Dysregulate Histone Acetylation and Impact the Outcome Of Chronic Lymphocytic Leukemia Patients
  

  Primary Author; Presenting Author: Alberto Rodríguez Sánchez, BSc – Cancer Research Center, USAL

  Co-Author: Miguel Quijada Álamo, PhD – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center. Department of Hematology, University Hospital of Salamanca

  Co-Author: Claudia Pérez Carretero, PhD – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center. Department of Hematology, University Hospital of Salamanca

  Co-Author: Luis A. Corchete Sánchez, PhD – Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129; Harvard Medical School, Boston, MA 02215; Broad Institute of MIT and Harvard, Cambridge, MA 02139

  Co-Author: Cristina Miguel García, BSc – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center. Department of Hematology, University Hospital of Salamanca, Salamanca

  Co-Author: Sandra Santos Mínguez, BSc – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center. Department of Hematology, University Hospital of Salamanca, Salamanca

  Co-Author: Eva Lumbreras González, BSc – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center. Department of Hematology, University Hospital of Salamanca, Salamanca

  Co-Author: Julio Dávila Valls, BSc – Department of Hematology, Hospital Nuestra Señora de Sonsoles

  Co-Author: Alfonso García De Coca – Department of Hematology. Hospital Clínico, Valladolid

  Co-Author: María Jesús Vidal Manceñido, PhD – Hospital de León

  Co-Author: Rocío Benito Sánchez, PhD – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center. Department of Hematology, University Hospital of Salamanca

  Co-Author: Ana E Rodríguez Vicente, PhD – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center. Department of Hematology, University Hospital of Salamanca

  Co-Author: Jesús María Hernández Rivas, MD, PhD – University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain; Department of Hematology, University Hospital of Salamanca
• 8:50 AM – 8:55 AM EDT

  Inhibition of G protein-coupled receptor kinase 2 (GRK2) as a strategy to modulate leukemic cell homing and activation in CLL
  

  Primary Author: Chiara Cassarino – IMEX-CONICET-ANM

  Co-Author: Ana Colado, PhD – IMEX-CONICET-ANM

  Co-Author: Valeria J. Sarapura Martinez, MD – Instituto de Medicina Experimental - CONICET - Academia Nacional de Medicina

  Co-Author: Martín Bertini, MD – Hospital Alvarez

  Co-Author: Claudio Martines, PhD – International Centre for Genetic Engineering and Biotechnology

  Co-Author: Alice Bonato, PhD – International Centre for Genetic Engineering and Biotechnology

  Co-Author: Miguel A. Pavlovksy, MD – FUNDALEU, Clinical Research Center Buenos Aires

  Co-Author: Rosario Custidiano, MD – Instituto Alexander Fleming

  Co-Author: Gregorio Cordini, MD – Laboratorio de Inmunología Oncológica, Instituto de Medicina Experimental (IMEX), CONICET-Academia Nacional de Medicina (ANM), Pacheco de Melo 3081, 1425

  Co-Author: Fernando R Bezares, MD – Sección de Hematología, Hospital General de Agudos Dr. Teodoro Álvarez

  Co-Author: Mónica Vermeulen, PhD – IMEX-CONCIET-ANM

  Co-Author: Romina Gamberale, PhD – IMEX-CONICET-ANM

  Co-Author: Mirta Giordano, PhD – IMEX-CONICET-ANM

  Co-Author: Dimitar G. Efremov, MD – International Centre for Genetic Engineering and Biotechnology

  Co-Author; Presenting Author: Mercedes Borge, PhD – IMEX-CONICET-ANM
• 8:55 AM – 9:00 AM EDT

  m6A-modified circTET2 interacting with HNRNPC regulates fatty acid oxidation to promote the proliferation of chronic lymphocytic leukemia
  

  Primary Author; Presenting Author: Hui Jin, MD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Zijuan Wu, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Huayuan Zhu, MD – the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Renfu Gui, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Jianyong Li, MD, PhD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Wei Zhang, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Lei Fan, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University
• 9:00 AM – 9:05 AM EDT

  Refining the phenotypic and functional intraclonal complexity in chronic lymphocytic leukemia B cells uncovers a discrepancy between surface membrane IG levels and time since birth supporting the requirement for multifactorial activation and different subclonal sensitivities to treatment.
  

  Primary Author; Presenting Author: Andrea N. Mazzarello, PhD – University of Genova

  Co-Author: Mark Fitch, M.Sc. – Department of Nutritional Sciences & Toxicology, University of California at Berkeley

  Co-Author: Martina Cardillo, PhD – The Feinstein Institutes for Medical Research, Northwell Health

  Co-Author: Anita Ng, PhD – The Feinstein Institutes for Medical Research, Northwell Health

  Co-Author: Sabreen Bhuiya, M.Sc. – The Feinstein Institutes for Medical Research, Northwell Health

  Co-Author: Esha Sharma, B.Sc. – The Feinstein Institutes for Medical Research, Northwell Health

  Co-Author: Chiara Salvetti, MD – Department of Internal Medicine, Clinic of Hematology, University of Genoa

  Co-Author: Jonathan E. Kolitz, MD – Zucker School of Medicine at Hofstra/Northwell

  Co-Author: Steven L. L. Allen, MD – Zucker School of Medicine at Hofstra/Northwell

  Co-Author: Kanti R. Rai, MD, PhD – Zucker School of Medicine at Hofstra/Northwell

  Co-Author: Joanna Rhodes, MD – Rutgers Cancer Institute of New Jersey

  Co-Author: Marc K. Hellerstein, MD, PhD – Department of Nutritional Sciences & Toxicology, University of California at Berkeley

  Co-Author: Nicholas Chiorazzi, MD, PhD – The Feinstein Institutes for Medical Research, Northwell Health
• 9:05 AM – 9:10 AM EDT

  Transcription factor FoxO1 Mediates Adaptive Increase in Akt Activity and Cell Survival During BCR Inhibitor Therapy in CLL
  

  Primary Author; Presenting Author: Marek Mraz, MD, PhD – CEITEC MU, Brno, Czech Rep.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Laura Ondrisova, MSc – CEITEC MU, Brno, Czech Rep.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Vaclav Seda, PhD – CEITEC MU, Brno, Czech Rep.; University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Eva Hoferkova, MSc – CEITEC MU, Brno, Czech Rep.; University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Giorgia Chiodin, PhD – Cancer Sciences, Faculty of Medicine, University of Southampton

  Co-Author: Krystof Hlavac, MSc – CEITEC MU, Brno, Czech Rep.; University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Lenka Kostalova, MSc – CEITEC MU, Brno, Czech Rep.; University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Gabriela Mladonicka Pavlasova, PhD – CEITEC MU, Brno, Czech Rep.; University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Daniel Filip, MSc – CEITEC MU, Brno, Czech Rep.; University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Pedro F. Faria Zeni, PhD – CEITEC MU

  Co-Author: Jan Oppelt, PhD – CEITEC MU

  Co-Author: Anna Panovska, MD – Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Karla Plevova, PhD – Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Sarka Pospisilova, Professor – Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Martin Šimkovič, MD, PhD – 4th Department of Internal Medicine – Hematology, University Hospital Hradec Králové

  Co-Author: Filip Vrbacký, RNDr., PhD. – 4th Department of Internal Medicine – Hematology, University Hospital and Charles University Faculty of Medicine in Hradec Králové

  Co-Author: Daniel Lysak, MD – Department of Haematology and Oncology, University Hospital Pilsen

  Co-Author: Stacey M. Fernandes, BS – Dana-Farber Cancer Institute

  Co-Author: Matthew S. Davids, MD, MMSc – Dana-Farber Cancer Institute (DFCI)

  Co-Author: Alba Maiques-Diaz, PhD – Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

  Co-Author: Stella Charalampopoulou, MSc – Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

  Co-Author: Jose I. Martin-Subero, PhD – Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

  Co-Author: Jennifer R. Brown, MD, PhD – Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI); Department of Medicine, Harvard Medical School (HMS)

  Co-Author: Michael Doubek, Professor – Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University

  Co-Author: Francesco Forconi, MD, DM, PhD, FRCPath – Cancer Sciences, Faculty of Medicine, University of Southampton

  Co-Author: Jiri Mayer, Professor – Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University
• 9:10 AM – 9:20 AM EDT

  Session 1: Panel Discussion