Session 6: Mechanisms of Resistance

Co-Chair(s)

• 

  Jennifer Woyach, MD

  Professor of Medicine
  Division of Hematology, Department of Internal Medicine, The Ohio State University
  The Ohio State University Comprehensive Cancer Center
  Columbus, OH, United States
• 

  Marek Mraz, MD, PhD

  PI
  CEITEC MU, Brno, Czech Rep.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University
  Brno, Czech Republic

Presentations:

• 11:20 AM – 11:35 AM EDT

  Resistance to Covalent BTKi
  

  Speaker: Adrian Wiestner, MD, PhD – Laboratory of Lymphoid Malignancies, National Heart, Lung, and Blood Institute, National Institutes of Health
• 11:35 AM – 11:50 AM EDT

  Resistance to Non-Covalent BTKi
  

  Speaker: Varsha Gandhi, PhD – The University of Texas MD Anderson Cancer Center
• 11:50 AM – 12:05 PM EDT

  Resistance to BCL2i
  

  Speaker: Rachel Thijssen, PhD – Amsterdam UMC / CCA
• 12:05 PM – 12:15 PM EDT

  Bruton’s Tyrosine Kinase and Phospholipase C-Gamma 2 Mutational Profiles in Pooled Analysis of Patients With Chronic Lymphocytic Leukemia Treated With Ibrutinib
  

  Primary Author; Presenting Author: Inhye E. Ahn, MD – Dana-Farber Cancer Institute

  Co-Author: Adrian Wiestner, MD, PhD – Laboratory of Lymphoid Malignancies, National Heart, Lung, and Blood Institute, National Institutes of Health

  Co-Author: Paolo Ghia, MD, PhD – Strategic Research Program on Chronic Lymphocytic Leukemia, Division of Experimental Oncology, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy

  Co-Author: John C. Byrd, MD – University of Cincinnati College of Medicine

  Co-Author: Carol Moreno, MD, PhD – Hospital de la Santa Creu i Sant Pau, and the Josep Carreras Leukaemia Research Institute

  Co-Author: Susan M. O'Brien, MD – Chao Family Comprehensive Cancer Center, University of California, Irvine

  Co-Author: Daniel Jones, MD, PhD – The Ohio State University Comprehensive Cancer Center

  Co-Author: Vincent Girardi, MA – AbbVie Inc.

  Co-Author: Leo W.-K. Cheung, PhD – AbbVie Inc.

  Co-Author: Melih Acar, PhD – AbbVie Inc.

  Co-Author: Shiquan Wu, PhD – AbbVie Inc.

  Co-Author: James P. Dean, MD, PhD – AbbVie Inc.

  Co-Author: Sima Patel, PhD – AbbVie Inc.

  Co-Author: Jennifer A. Woyach, MD – Division of Hematology, Department of Internal Medicine, The Ohio State University
• 12:15 PM – 12:25 PM EDT

  Mutations Detected in Real World Clinical Sequencing during BTK Inhibitor Treatment in Chronic Lymphocytic Leukemia (CLL)
  

  Primary Author; Presenting Author: Kiyomi Mashima, MD, PhD – Dana-Farber Cancer Institute

  Co-Author: Stacey M. Fernandes, BS – Dana-Farber Cancer Institute

  Co-Author: Samantha Shupe, BS – Dana-Farber Cancer Institute

  Co-Author: Rayan Fardoun, BS – Dana-Farber Cancer Institute

  Co-Author: Aishath Naeem, PhD – Dana-Farber Cancer Institute

  Co-Author: Matthew S. Davids, MD, MMSc – Dana-Farber Cancer Institute (DFCI)

  Co-Author: Jennifer R. Brown, MD, PhD – Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI); Department of Medicine, Harvard Medical School (HMS)
• 12:25 PM – 12:35 PM EDT

  Recurrent Genomic Alterations in the Apoptotic Machinery in Patients With CLL Treated With Venetoclax Monotherapy Following Treatment With BCRi
  

  Primary Author; Presenting Author: Jennifer A. Woyach, MD – Division of Hematology, Department of Internal Medicine, The Ohio State University

  Co-Author: Relja Popovic, PhD – AbbVie Inc.

  Co-Author: Emily Rossi, N/A – AbbVie Inc.

  Co-Author: Sanjana Singh, MA – AbbVie Inc.

  Co-Author: Xifeng Wang, PhD – AbbVie Inc.

  Co-Author: Toshihiko Oki, MD, PhD – AbbVie Inc.

  Co-Author: Tanya S. Rosenberg, PhD – AbbVie Inc.

  Co-Author: Chen Qian, N/A – AbbVie Inc.

  Co-Author: Michael Moran, MA, PhD – AbbVie Inc.

  Co-Author: Michelle Boyer, PhD – Genentech Inc

  Co-Author: Jeffrey Jones, PhD – Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

  Co-Author: Richard R. Furman, MD – Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine

  Co-Author: Jason Gotlib, MD – Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

  Co-Author: Stephen J. Schuster, MD – Lymphoma Program, Abramson Cancer Center, University of Pennsylvania

  Co-Author: Brenda Chyla, PhD – AbbVie Inc.

  Co-Author: Matthew S. Davids, MD, MMSc – Dana-Farber Cancer Institute (DFCI)
• 12:35 PM – 12:40 PM EDT

  Genomic Evolution and Resistance to Pirtobrutinib in Covalent BTK-Inhibitor Pre-treated Chronic Lymphocytic Leukemia Patients: Results from the Phase I/II BRUIN Study
  

  Primary Author; Presenting Author: Jennifer R. Brown, MD, PhD – Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI); Department of Medicine, Harvard Medical School (HMS)

  Co-Author: Sai Prasad Desikan, N/A – University of Texas MD Anderson Cancer Center

  Co-Author: Bastien Nguyen, N/A – Loxo@Lilly

  Co-Author: Helen Won, N/A – Loxo@Lilly, Indianapolis

  Co-Author: Shady I. Tantawy, N/A – University of Texas MD Anderson Cancer Center

  Co-Author: Samuel C. McNeely, N/A – Eli Lilly and Company

  Co-Author: Narasimha Marella, N/A – Loxo@Lilly

  Co-Author: Kevin Ebata, N/A – Loxo@Lilly

  Co-Author: Jennifer A. Woyach, MD – Division of Hematology, Department of Internal Medicine, The Ohio State University

  Co-Author: Krish Patel, MD – Swedish Cancer Institute

  Co-Author: Constantine S. Tam, MD, MBBS – Alfred Hospital and Monash University

  Co-Author: Toby A. A. Eyre, MD – Churchill Cancer Center, Oxford University Hospitals NHS Foundation Trust

  Co-Author: Chan Y. Y. Cheah, MD – Linear Clinical Research and Sir Charles Gairdner Hospital and University of Western Australia

  Co-Author: Nirav N. Shah, MD – Medical College of Wisconsin

  Co-Author: Paolo Ghia, MD, PhD – Strategic Research Program on Chronic Lymphocytic Leukemia, Division of Experimental Oncology, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy

  Co-Author: Wojciech Jurczak, MD, PhD – Maria Skłodowska-Curie National Research Institute of Oncology

  Co-Author: Minna Balbas, N/A – Loxo@Lilly

  Co-Author: Binoj Nair, N/A – Loxo@Lilly

  Co-Author: Paolo Abada, N/A – Loxo@Lilly

  Co-Author: Chunxiao Wang, PhD – Eli Lilly and Company

  Co-Author: Denise Wang, N/A – Loxo@Lilly

  Co-Author: Anthony R. Mato, MD – Memorial Sloan Kettering Cancer Center

  Co-Author: Varsha Gandhi – The University of Texas MD Anderson Cancer Center

  Co-Author: William G. Wierda, MD, PhD – University of Texas MD Anderson Cancer Center
• 12:40 PM – 12:55 PM EDT

  Panel Discussion With Interactivity and Audience Q&A Theme: "Targeted Strategies to Overcome Resistance"