Session 8: Richter's Transformation - From Biology to Clinic

Co-Chair(s)

• 

  Inhye Ahn, MD

  Assistant Professor
  Dana-Farber Cancer Institute
  Boston, MA, United States
• 

  Lili Wang, MD, PhD

  Associate Professor, Department of Systems Biology
  Beckman Research Institute, City of Hope National Comprehensive Cancer Center, Monrovia; Toni Stephenson Lymphoma Center, Beckman Research Institute, City of Hope Comprehensive Cancer Center
  Duarte, CA, United States

Presentations:

• 8:15 AM – 8:25 AM EDT

  In Vivo Modeling of CLL Transformation: PDX Model
  

  Speaker: Silvia Deaglio, MD, PhD – University of Turin
• 8:25 AM – 8:35 AM EDT

  In Vivo Modeling of CLL Transformation: Multiplex In Vivo CRISPR Editing
  

  Speaker: Elisa ten Hacken, PhD – Weill Cornell Medicine
• 8:35 AM – 8:45 AM EDT

  In Vivo Modeling of CLL Transformation: TP53 and CDKN2a/b Model
  

  Speaker: Dimitar G. Efremov, MD – International Centre for Genetic Engineering and Biotechnology
• 8:45 AM – 8:55 AM EDT

  Panel Discussion on In Vivo Modeling
  

  Speaker: Elisa ten Hacken, PhD – Weill Cornell Medicine

  Speaker: Dimitar G. Efremov, MD – International Centre for Genetic Engineering and Biotechnology

  Speaker: Silvia Deaglio, MD, PhD – University of Turin
• 8:55 AM – 9:05 AM EDT

  Mitochondrial dysregulation and metabolite imbalance in Richter’s Transformation: Insights from a mouse model
  

  Primary Author; Presenting Author: Prajish S. Iyer, PhD – Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer Center

  Co-Author: Bo Zhang, MD, PhD – Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer Center

  Co-Author: Tingting Liu, PhD – City of Hope National Medical Center

  Co-Author: Meiling Jin, PhD – Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer Center

  Co-Author: Kevyn Hart, MS – Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer Center

  Co-Author: Joo Y Song, MD – Department of Pathology, City of Hope National Comprehensive Cancer Center

  Co-Author: Wing C. Chan, MD – Department of Pathology, Toni Stephenson Lymphoma Center, Beckman Research Institute, City of Hope Comprehensive Cancer Center

  Co-Author: Tanya Siddiqi, MD – City of Hope National Medical Center

  Co-Author: Steven Rosen, MD – Department of Hematology& Hematopoietic Cell Transplantation, Toni Stephenson Lymphoma Center, Beckman Research Institute, City of Hope Comprehensive Cancer Center

  Co-Author: Alexey V. Danilov, MD, PhD – Department of Hematology and Transplantation;
  City of Hope National Medical Center

  Co-Author: Lili Wang, MD, PhD – Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer Center, Monrovia; Toni Stephenson Lymphoma Center, Beckman Research Institute, City of Hope Comprehensive Cancer Center
• 9:05 AM – 9:10 AM EDT

  Sequencing of circulating tumour DNA reveals additional driver mutations in Richter Transformation
  

  Primary Author; Presenting Author: Niamh Appleby, MRCPI FRCPath (Haem) – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford

  Co-Author: Sitara Akbar, BSc – University of Oxford, Department of Oncology

  Co-Author: Anthony Cutts, PhD – Oxford Molecular Diagnostics Centre

  Co-Author: Hélène Dreau, MSc – Oxford Molecular Diagnostics Centre

  Co-Author: Georgeta Ciuban, BSc – University of Oxford, Department of Oncology

  Co-Author: Thomas Wenban-Smith, BSc – Oxford Molecular Diagnostics Centre

  Co-Author: Melinda Kormany, Laboratory Assistant – Oxford Molecular Diagnostics Centre

  Co-Author: Kieran Howard, Clinical Bioinformatician – Oxford Molecular Diagnostics Centre

  Co-Author: Grigore-Aristide Gafencu, BMBS, DPhil – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford

  Co-Author: Kate Ridout, D.Phil – Oxford Molecular Diagnostics Centre

  Co-Author: Dimitris Vavoulis, BSc, MRes, MSc, PhD – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford, Oxford, United Kingdom Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  Co-Author: Rebecca Boucher, Senior Biostatistician – Cancer Research UK Clinical Trials Unit, University of Birmingham

  Co-Author: Nicola Jackson, Biostatistician – Cancer Research UK Clinical Trials Unit, University of Birmingham

  Co-Author: Joseph A. Rogers, MSc – Cancer Research UK Clinical Trials Unit, University of Birmingham

  Co-Author: Francesca Yates, PhD – Cancer Research UK Clinical Trials Unit, University of Birmingham

  Co-Author: Aimee Jackson, Principal Biostatistician – Cancer Research UK Clinical Trials Unit, University of Birmingham

  Co-Author: Sonia Fox, BSc – Institute of Cancer and Genomic Sciences, University of Birmingham

  Co-Author: Toby A. A. Eyre, MD – Churchill Cancer Center, Oxford University Hospitals NHS Foundation Trust

  Co-Author: Anna Schuh, MD, PhD, FRCP, FRCPath – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford
• 9:10 AM – 9:15 AM EDT

  Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation
  

  Primary Author; Presenting Author: Heribert Playa-Albinyana, BSc, MSc – Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

  Co-Author: Fabian Arenas, PhD – Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain;

  Co-Author: Romina Royo, PhD – Barcelona Supercomputing Center

  Co-Author: Ariadna Giró, N/A – Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

  Co-Author: Irene Lopez-Oreja, PhD student – Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centre for Genomic Regulation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Universidad Pompeu Fabra, Barcelona, Spain.

  Co-Author: Marta Aymerich, MD – Hospital Clínic de Barcelona

  Co-Author: Monica Lopez-Guerra, PhD – Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Hospital Clinic de Barcelona,

  Co-Author: Gerard Frigola, PhD – Hospital Clínic de Barcelona

  Co-Author: Sílvia Beà, PhD – Hospital Clínic de Barcelona

  Co-Author: Julio Delgado, MD – Servicio de Hematología, Hospital Clínic, IDIBAPS

  Co-Author: Pablo M. Garcia-Roves, PhD – University of Barcelona

  Co-Author: Elias Campo, MD, PhD – Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain

  Co-Author: Ferran Nadeu, PhD – Fundació de Recerca Clínic Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS)

  Co-Author: Dolors Colomer, PhD – Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain
• 9:15 AM – 9:25 AM EDT

  Chemoimmunotherapy and BCR-Targeted Agents for Richter's Transformation
  

  Speaker: Sameer A. Parikh, MBBS – Mayo Clinic
• 9:25 AM – 9:35 AM EDT

  Investigational Therapies for Richter's Transformation: Bispecifics
  

  Speaker: Philip Thompson, MBBS (Hons) – Department of Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre and The Sir Peter MaCallum Department of Clinical Oncology, University of Melbourne
• 9:35 AM – 9:45 AM EDT

  Investigational Therapies for Richter's Transformation: Cellular Therapies
  

  Speaker: Tanya Siddiqi, MD – City of Hope National Medical Center
• 9:45 AM – 9:55 AM EDT

  Panel Discussion With Interactivity and Audience Q&A