YIM Session 3: Translational Research in CLL

Co-Chair(s)

• FP

  Fleur S. Peters, PhD

  Postdoctoral Researcher
  Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Lymphoma and Myeloma Center Amsterdam
  Amsterdam, Netherlands
• 

  Marek Mraz, MD, PhD

  PI
  CEITEC MU, Brno, Czech Rep.; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University
  Brno, Czech Republic

Presentations:

• 10:25 AM – 10:35 AM EDT

  Increased susceptibility to Streptococcus pneumoniae pulmonary infection in the Eµ-TCL1 adoptive transfer mouse model of CLL
  

  Primary Author; Presenting Author: Ana Colado, PhD – IMEX-CONICET-ANM

  Co-Author: Juliana Bernatowiez, N/A

  Co-Author: Chiara Cassarino – IMEX-CONICET-ANM

  Co-Author: Valeria J. Sarapura Martinez, MD – Instituto de Medicina Experimental - CONICET - Academia Nacional de Medicina

  Co-Author: Martín Bertini, MD – Hospital Alvarez

  Co-Author: Fernando R Bezares, MD – Sección de Hematología, Hospital General de Agudos Dr. Teodoro Álvarez

  Co-Author: Mónica Vermeulen, PhD – IMEX-CONCIET-ANM

  Co-Author: Romina Gamberale, PhD – IMEX-CONICET-ANM

  Co-Author: Mirta Giordano, PhD – IMEX-CONICET-ANM

  Co-Author: Mercedes Borge, PhD – IMEX-CONICET-ANM
• 10:35 AM – 10:45 AM EDT

  NX-2127 and NX-5948, two clinical stage cereblon-recruiting BTK degraders, facilitate T-cell functionality in CLL
  

  Primary Author; Presenting Author: Tiana Huynh, PhD Candidate – City of Hope - Irell and Manella Graduate School of Biological Sciences

  Co-Author: Sonia Rodriguez-Rodriguez, PhD

  Co-Author: Carly Roleder, N/A

  Co-Author: Janine Powers, PhD

  Co-Author: Alexey V. Danilov, MD, PhD – Department of Hematology and Transplantation;
  City of Hope National Medical Center
• 10:45 AM – 10:55 AM EDT

  Single-cell transcriptomic analysis of CLL cells at ibrutinib plus venetoclax relapse and targeting using BCL-2/BCL-xL PROTACs PZ18753b and WH25244
  

  Primary Author; Presenting Author: Daisy Diaz Rohena, BS – University of Texas MD Anderson Cancer Center

  Co-Author: Arnau Peris Cuesta, N/A – University of Texas MD Anderson Cancer Center

  Co-Author: Bailey Slawin, N/A

  Co-Author: Janani Ravikrishnan, PhD – Division of Hematology, Department of Internal Medicine, The Ohio State University, 410 W 12Th Avenue

  Co-Author: Chaomei Liu, TX, N/A – University of Texas MD Anderson Cancer Center

  Co-Author: Charmelle Williams, MS, BS – The University of Texas MD Anderson UTHealth Houston Graduate School of Biomedical Sciences

  Co-Author: Wanyi Hu, N/A

  Co-Author: Peiyi Zhang, N/A

  Co-Author: Philip Thompson, MBBS (Hons) – Department of Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre and The Sir Peter MaCallum Department of Clinical Oncology, University of Melbourne

  Co-Author: William G. Wierda, MD, PhD – University of Texas MD Anderson Cancer Center

  Co-Author: Nitin Jain, MD – University of Texas MD Anderson Cancer Center

  Co-Author: Sachet Ashok Shukla, PhD, MS – University of Texas MD Anderson Cancer Center

  Co-Author: Guangrong Zheng, PhD – University of Florida

  Co-Author: Daohong Zhou, MD – UTHealth Science Center at San Antonio

  Co-Author: Jennifer A. Woyach, MD – Division of Hematology, Department of Internal Medicine, The Ohio State University

  Co-Author: Deepa Sampath, PhD – Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center
• 10:55 AM – 11:05 AM EDT

  T-cell Transcriptional and Mitochondrial Fitness Reprogramming in CLL Using PI3Kδ Inhibitors
  

  Primary Author; Presenting Author: Wael Gamal, MSc – H Lee Moffitt Cancer Center & Research Institute

  Co-Author: Melanie Mediavilla-Varela, PhD – H Lee Moffitt Cancer Center & Research Institute

  Co-Author: Kamira Maharaj, PhD – AstraZeneca

  Co-Author: Angimar Uriepero, MD, MMSc – H Lee Moffitt Cancer Center & Research Institute

  Co-Author: Vishaal Kunta, N/A – H Lee Moffitt Cancer Center & Research Institute

  Co-Author: Eva Sahakian, PhD – H Lee Moffitt Cancer Center & Research Institute

  Co-Author: Javier Pinilla-Ibarz, MD, PhD – H Lee Moffitt Cancer Center & Research Institute
• 11:05 AM – 11:10 AM EDT

  Identification of novel targets that upregulate CD20 expression in rituximab-resistant cells with the use of genome-wide CRISPR screening
  

  Primary Author; Presenting Author: Lenka Dostalova, MSc – CEITEC Masaryk University

  Co-Author: Aneta Ledererova, MSc, PhD – Central European Institute of Technology, Masaryk University

  Co-Author: Helena Peschelova, MSc – Central European Institute of Technology, Masaryk University

  Co-Author: Tomas Loja, MSc, PhD – Central European Institute of Technology, Masaryk University

  Co-Author: Michal Smida, MSc, PhD – Central European Institute of Technology (CEITEC), Masaryk University; Department of Internal Medicine - Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno
• 11:10 AM – 11:15 AM EDT

  Integrating Multi-Omics to Reveal the Heterogeneous Clonal Evolutionary Characteristics in CLL Patients with Zanubrutinib Resistance
  

  Primary Author; Presenting Author: Huayuan Zhu, MD – the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Yeqin Sha, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Yi Miao, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Shuchao Qin, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Luomengjia Dai, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Tonglu Qiu, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Rui Jiang, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Wei Wu, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Yi Xia, MD – the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Lei Fan, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Wei Xu, MD, PhD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Hui Jin, MD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Jianyong Li, MD, PhD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital
• 11:15 AM – 11:20 AM EDT

  Single-cell RNA sequencing Reveals the Spatial Heterogeneity in BTKi-Resistant Richter Transformation Patients
  

  Primary Author: Yeqin Sha, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Shuchao Qin, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Yi Miao, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Yi Xia, MD – the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Xiao Lu, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Luomengjia Dai, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Tonglu Qiu, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Wei Wu, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Lei Fan, Dr – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Wei Xu, MD, PhD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author: Hui Jin, MD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University

  Co-Author: Jianyong Li, MD, PhD – Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital

  Co-Author; Presenting Author: Huayuan Zhu, MD – the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital
• 11:20 AM – 11:25 AM EDT

  T cell type abundance and gene expression patterns in the context of clinical progression of treatment-naïve CLL/MBL patients from the OxPLoreD study
  

  Primary Author; Presenting Author: Grigore-Aristide Gafencu, BMBS, DPhil – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford

  Co-Author: Niamh Appleby, MRCPI FRCPath (Haem) – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford

  Co-Author: Charlotte Rich-Griffin, PhD – Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford

  Co-Author: Kyla Dooley, MSc – Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford

  Co-Author: Holm Uhlig, MD, DPhil – Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford

  Co-Author: Calliope Dendrou, BSc, PhD – Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
  The Kennedy Institute of Rheumatology, University of Oxford

  Co-Author: Dimitris Vavoulis, BSc, MRes, MSc, PhD – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford, Oxford, United Kingdom Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

  Co-Author: Anna Schuh, MD, PhD, FRCP, FRCPath – Oxford Molecular Diagnostic Centre, Department of Oncology, University of Oxford
• 11:25 AM – 11:30 AM EDT

  The PKCβ inhibitor MS-553 displays preclinical efficacy in BTK inhibitor resistant Chronic Lymphocytic Leukemia
  

  Primary Author; Presenting Author: Britten Gordon, BS – The Ohio State University

  Co-Author: Elizabeth Muhowski, PhD – Division of Pharmaceutics, College of Pharmacy, The Ohio State University

  Co-Author: Janani Ravikrishnan, PhD – Division of Hematology, Department of Internal Medicine, The Ohio State University, 410 W 12Th Avenue

  Co-Author: Shanmugapriya Thangavadivel, PhD – The Ohio State University

  Co-Author: Samon Benrashid, BS – Hematology Oncology Translational Research Laboratory, Levine Cancer Institute/Atrium Health

  Co-Author: Alexander He, BS

  Co-Author: Shrilekha Misra, PhD – Division of Hematology, Department of Internal Medicine, The Ohio State University

  Co-Author: Tzung-Huei Lai, PhD, DVM – Division of Hematology, Department of Internal Medicine, The Ohio State University

  Co-Author: Alexander Marr, BS

  Co-Author: Brandi Walker, N/A – Division of Hematology, Department of Internal Medicine, The Ohio State University

  Co-Author: Elizabeth Perry, N/A – The Ohio State University

  Co-Author: Nicole Grieselhuber, MD, PhD – The Ohio State University Comprehensive Cancer Center, The Ohio State University

  Co-Author: Kerry A. Rogers, MD – The Ohio State University

  Co-Author: James Blachly, MD – Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital

  Co-Author: Adam S. Kittai, MD – The Ohio State University Comprehensive Cancer Center

  Co-Author: Seema A. Bhat, MD – The Ohio State University Comprehensive Cancer Center

  Co-Author: John C. Byrd, MD – University of Cincinnati College of Medicine

  Co-Author: Michael Niesman, PhD – MingSight Pharmaceuticals, Inc.

  Co-Author: Kai Zhang, MD

  Co-Author: Deepa Sampath, PhD – Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center

  Co-Author: Jennifer A. Woyach, MD – Division of Hematology, Department of Internal Medicine, The Ohio State University
• 11:30 AM – 11:35 AM EDT

  Toll-like receptor 9 signalling in CLL: a resistance mechanism to B-cell receptor-targeted treatments, and a potential tool for therapeutic stratification.
  

  Primary Author; Presenting Author: Emma M. Kennedy, PhD – Brighton and Sussex Medical School

  Co-Author: Lauren Stott, MSc – Brighton and Sussex Medical School

  Co-Author: Eleanor Jayawant, PhD – Brighton and Sussex Medical School

  Co-Author: Rosalynd Johnston, MB – Brighton and Sussex University Hospital Trust

  Co-Author: John Jones, MB/PhD – East Sussex Healthcare NHS Trust

  Co-Author: Eleni Ladikou, MB – Brighton and Sussex Medical School

  Co-Author: Iona Ashworth, MB – Brighton and Sussex Medical School

  Co-Author: Valter Gattei, Professor – Centro di Riferimento Oncologico di Aviano (CRO) IRCCS

  Co-Author: Antonella Zucchetto, PhD – Centro di Riferimento Oncologico di Aviano (CRO) IRCCS

  Co-Author: Simon Mitchell, PhD – Brighton and Sussex Medical School

  Co-Author: Chris Pepper, Professor – Brighton and Sussex Medical School

  Co-Author: Andrea Pepper, Professor – Brighton and Sussex Medical School
• 11:35 AM – 11:40 AM EDT

  XPO1 mutations identify early stage CLL characterized by shorter time to first treatment and enhanced BCR signaling
  

  Primary Author; Presenting Author: Riccardo Moia, MD – Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont

  Co-Author: Donatella Talotta, Dr – Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Lodovico Terzi di Bergamo, MD – Institute of Oncology Research, Università della Svizzera Italiana

  Co-Author: Riccardo Bomben, Dr – Centro di Riferimento Oncologico di Aviano (CRO) IRCCS

  Co-Author: Gabriela Forestieri, Dr – Laboratory of Experimental Hematology, Institute of Oncology Research

  Co-Author: Valeria Spina, Dr – Institute of Oncology Research

  Co-Author: Alessio Bruscaggin, Dr – Institute of Oncology Research

  Co-Author: Chiara Cosentino, Dr

  Co-Author: Mohammad Almasri, Dr – Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Riccardo Dondolin, Dr – Division of Hematology, Department of Translational Medicine, Università Del Piemonte Orientale

  Co-Author: Tamara Bittolo, PhD – Centro di Riferimento Oncologico di Aviano (CRO) IRCCS

  Co-Author: Antonella Zucchetto, PhD – Centro di Riferimento Oncologico di Aviano (CRO) IRCCS

  Co-Author: Stefano Baldoni, Dr – Department of Life, Hematology Section, Health and Environmental Sciences, University of L'Aquila

  Co-Author: Ilaria del Giudice, Dr – Policlinico Umberto I, Università "La Sapienza," Istituto Ematologia, Dipartimento di Medicina Traslazionale e di Precisione

  Co-Author: Francesca Romana Mauro, Dr – Department of Translational and Precision Medicine, Hematology unit, 'Sapienza' University

  Co-Author: Rossana Maffei, Dr – Department of Medical Sciences, Section of Hematology, University of Modena and Reggio Emilia

  Co-Author: Annalisa Chiarenza, Dr – Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania

  Co-Author: Agostino Tafuri, Dr – Azienda Ospedaliera Universitaria “Sant’Andrea” - Sapienza Università di Roma University Hospital “Sant’Andrea” - Sapienza, University of Rome

  Co-Author: Roberta Laureana, MD – Division of Haematology, University of Tor Vergata

  Co-Author: Maria Ilaria del Principe, MD – Università degli studi di Roma Tor Vergata

  Co-Author: Francesco Zaja, Dr – Department of Medical, Surgical and Health Sciences, University of Trieste

  Co-Author: Giovanni D'Arena, Dr – IRCCS Centro Di Riferimento Oncologico Della Basilicata

  Co-Author: Jacopo Olivieri, MD – Clinica Ematologia di Udine

  Co-Author: Silvia Rasi, Dr – University of Eastern Piedmont

  Co-Author: Abdurraouf Mahmoud, Dr – Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Wael Al Essa, Dr – ivision of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Bassel Awikeh, Dr – Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Sreekar Kogila, Dr – Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Matteo Bellia, Dr – Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Samir Mouhssine, Mr – Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

  Co-Author: Paolo Sportoletti, MD – A.O. Santa Maria della Misericordia di Perugia

  Co-Author: Roberto Marasca, Dr – Department of Medical Sciences, Section of Hematology, University of Modena and Reggio Emilia

  Co-Author: Lydia Scarfò, MD – Vita-Salute San Raffaele University

  Co-Author: Paolo Ghia, MD, PhD – Strategic Research Program on Chronic Lymphocytic Leukemia, Division of Experimental Oncology, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy

  Co-Author: Valter Gattei, Professor – Centro di Riferimento Oncologico di Aviano (CRO) IRCCS

  Co-Author: Robin Foà, Professor – Department of Translational and Precision Medicine, Hematology unit, 'Sapienza' University

  Co-Author: Davide Rossi, Professor – Institute of Oncology Research

  Co-Author: Gianluca Gaidano, Professor – Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont
• 11:40 AM – 11:50 AM EDT

  Session 3: Panel Discussion