1140 - Pregnancy course of 10 women diagnosed with Chronic Lymphocytic Leukemia

Pregnancies following diagnosis of Chronic Lymphocytic Leukemia (CLL) are rare events, mainly because the disease is typically diagnosed in the elderly. Literature on the topic is based only on case reports, and limited data are available on the influence of pregnancy on CLL course.
In this retrospective study, we aimed to summarize the clinical and laboratory course of 10 women with CLL who became pregnant.
None of the patients had significant changes in blood count during or after pregnancy or had complications as infection, autoimmune phenomenon, or preeclampsia. Four out of 10 pregnancies were terminated with an early miscarriage. Following labor, One patients started anti-CLL treatment due to pre-exciting anemia, but none of the women required therapy during CLL progression during the first two years of follow-up.
We conclude that based on our serial; pregnancy doesn't impact negatively on CLL course.